Description:

Imagine a future where a diagnosis of a severe genetic disease is no longer terrifying because effective medicines can cure them. We are turning this vision into reality through pioneering work in genome editing and precision medicine. Join us in this effort!

Genome Engineering Team in Gothenburg, Sweden focuses on developing treatment for Rare Diseases. We continually push the boundaries of science to expand the limits of scientific research to better understand rare diseases, discover new life-changing treatments and deliver medicines to patients.

As a Senior Research Scientist, you will be a key member of the Genome Engineering Department. You will join our international team that develops novel genome engineering technologies and applies these breakthroughs to generate innovative gene therapies. We provide a stimulating environment with state-of-the-art facilities where you can transform cutting-edge genome engineering tools into effective and safe medicines.

What will you do:

In this laboratory-based role, you will leverage your scientific expertise in genome engineering and innovative thinking to develop novel tools and applications that can lead to breakthrough therapies. As a key member of cross-functional project teams, you will develop and evaluate genome editing strategies for specific disease projects. Accountabilities will include innovative optimization of genome engineering technologies to facilitate effective gene editing in target cell & tissue types, developing relevant assays, analyzing gene editing outcomes, documenting, interpreting, and communicating results to appropriate partners.

Desirable for the role: 

• Experience in metabolism research

• Understanding and previous hands-on experience with CRISPR-Cas9 technologies

• Hands-on experience with standard molecular biology approaches for quantifying protein levels (e.g. Western blot, ELISA) or measuring protein activity

• Experience working with lentiviral vectors for engineering cell models

For advertisement :

Fully competent in own research area within Bioscience discipline. Initiate, direct and perform research experiments and implementing strategies. Will be able to work without direct supervision and be able to advise/train less experienced scientists. May have supervisory role but not line management

Your accountabilities will include:

• Establishing and maintaining disease cell models using immortalized or iPSC cell lines

• Establishing and running cellular and biochemical assays to evaluate efficacy of therapeutic genome editing approaches in disease models

• Documenting, interpreting and communicating results to stakeholders and partners